Ascite/insufficienza renale/ACLF nella cirrosi
Area di afferenza: Gastroenterologia
SSD: MED/12
Responsabile: Dott. Carlo Alessandria
- Dott. Carlo Alessandria (responsabile)
- D.ssa Daniela Campion (vice-responsabile)
- Dott. Alberto Calleri (specializzando)
- Dott. Francesco Frigo (specializzando)
- Dott. Marco Tizzani (specializzando)
- Reparto di degenza della Gatsroenterologia, Città della Salute e della Scienza di Torino, sede Molinette, secondo piano, 011633-5569/5561
- Dott. Carlo Alessandria
- Ascite nella cirrosi
- AKI e CKD nella cirrosi
- ACLF (acute-on-chronic liver failure)
- Pubblicazioni - ultimi 3 anni
- Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial. Caraceni P, Riggio O, Angeli P, Alessandria C, Neri S, Foschi FG, Levantesi F, Airoldi A, Boccia S, Svegliati-Baroni G, Fagiuoli S, Romanelli RG, Cozzolongo R, Di Marco V, Sangiovanni V, Morisco F, Toniutto P, Tortora A, De Marco R, Angelico M, Cacciola I, Elia G, Federico A, Massironi S, Guarisco R, Galioto A, Ballardini G, Rendina M, Nardelli S, Piano S, Elia C, Prestianni L, Cappa FM, Cesarini L, Simone L, Pasquale C, Cavallin M, Andrealli A, Fidone F, Ruggeri M, Roncadori A, Baldassarre M, Tufoni M, Zaccherini G, Bernardi M; ANSWER Study Investigators. Lancet. 2018 Jun 16;391(10138):2417-2429. doi: 10.1016/S0140-6736(18)30840-7. Epub 2018 Jun 1. PMID: 29861076
- Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.Piano S, Singh V, Caraceni P, Maiwall R, Alessandria C, Fernandez J, Soares EC, Kim DJ, Kim SE, Marino M, Vorobioff J, Barea RCR, Merli M, Elkrief L, Vargas V, Krag A, Singh SP, Lesmana LA, Toledo C, Marciano S, Verhelst X, Wong F, Intagliata N, Rabinowich L, Colombato L, Kim SG, Gerbes A, Durand F, Roblero JP, Bhamidimarri KR, Boyer TD, Maevskaya M, Fassio E, Kim HS, Hwang JS, Gines P, Gadano A, Sarin SK, Angeli P; International Club of Ascites Global Study Group. Gastroenterology. 2019 Apr;156(5):1368-1380.e10. doi: 10.1053/j.gastro.2018.12.005. Epub 2018 Dec 13. PMID: 30552895
- The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology. Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Janicko M, Steib C, Reiberger T, Acevedo J, Gatti P, Bernal W, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Bendtsen F, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solè C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Özdogan OC, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Curto A, Pitarch C, Putignano A, Moreno E, Shawcross D, Aguilar F, Clària J, Ponzo P, Jansen C, Vitalis Z, Zaccherini G, Balogh B, Vargas V, Montagnese S, Alessandria C, Bernardi M, Ginès P, Jalan R, Moreau R, Angeli P, Arroyo V; PREDICT STUDY group of the EASL-CLIF Consortium. J Hepatol. 2020 Oct;73(4):842-854. doi: 10.1016/j.jhep.2020.06.013. Epub 2020 Jul 13. PMID: 32673741
- Endpoints and design of clinical trials in patients with decompensated cirrhosis: Position paper of the LiverHope Consortium. Solà E, Pose E, Campion D, Piano S, Roux O, Simon-Talero M, Uschner F, de Wit K, Zaccherini G, Alessandria C, Beuers U, Caraceni P, Francoz C, Mookerjee RP, Trebicka J, Vargas V, Serra M, Torres F, Montagnese S, Krag A, Hernaez R, Korenjak M, Watson H, Abraldes JG, Kamath PS, Ginès P; LiverHope Consortium Investigators. J Hepatol. 2021 Jan;74(1):200-219. doi: 10.1016/j.jhep.2020.08.009. Epub 2020 Sep 5. PMID: 32896580
- Assessment of glomerular filtration rate in patients with cirrhosis: Available tools and perspectives. Campion D, Rizzi F, Bonetto S, Giovo I, Roma M, Saracco GM, Alessandria C. Liver Int. 2022 Nov;42(11):2360-2376. doi: 10.1111/liv.15198. Epub 2022 Mar 21. PMID: 35182100
- CANONIC study – Acute-on-chronic liver failure in cirrhosis - European foundation for the study of chronic liver failure. Observational European multicenter study performed by the EASL-CLIF Consortium on the definition, development and outcome of acute-on-chronic liver failure
- INFECIR-2 study - Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality. European foundation for the study of chronic liver failure
- ANSWER study - Phase IV randomized Italian multicenter study on “The Use of Human Albumin for the Treatment of Ascites in Patients with Hepatic Cirrhosis: a Multicenter, Open-label Randomized Clinical Trial”
- LIVER HOPE study (Horizon 2020 - grant agreement No 731875) - Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis: a multicentre, double blind, placebo controlled randomized clinical trial.
- GLOBAL study - The epidemiology and the clinical impact of bacterial infections in hospitalized patients with cirrhosis: a multicenter observational prospective survey among the members of the International Club of Ascites. Prospective international observational study to define the epidemiology of bacterial infections in cirrhosis worldwide.
- PREDICT study - Protocol of the Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT). Study on behalf of the EASL-CLIF Consortium
- DECISION study (Horizon 2020 - grant agreement No 847949 - European foundation for the study of chronic liver failure). Decompensated Cirrhosis: Identification of new Combinatorial therapies based on system approaches. A novel COMBinATorial therapy with albumin and enoxaparin in patients with decompensated cirrhosis at high-risk of poor outcome (COMBAT trial). Ongoing. Link: https://decision-for-liver.eu/
- GLOBALl-AKI study (International Club of ascites) - Characteritics and management of acute kidney injury in hospitalized patients with cirrhosis: a multicenter intercontinental observational prospective study”. Ongoing. Link: https://clinicaltrials.gov/ct2/show/NCT05387811
- Decision Project (Horizon 2020 - grant agreement No 847949)
- Online Educational Event for Patients, March 6th 2023 (Carlo Alessandria)
- “Explanation of the recruitment process by a successful recruitment center / clinician”