Componenti

1. Frairia Roberto (Responsabile)
2. D'Angelo Valentina
3. Felicetti Francesco Carlo
4. Fortunati Nicoletta
5. Rinella Letizia
6. Zunino Valentina

Contatti

• 011-6709560 (prof. Arvat); 011-6705391 (prof. Frairia); 011-6705360 (dott. Catalano)
• Scrivi a tutti i componenti

Attività

Il Laboratorio nasce dalla fusione dei Laboratori di Endocrinologia e Radiobiologia & di Endocrinologia Oncologica e mette in comune le esperienze nel campo degli steroidi sessuali, loro recettori e proteine di trasporto (SHBG, CBG) e la ricerca di base e traslazionale in oncologia ed endocrinologia riguardante i tumori endocrini e ormono-dipendenti. Specifiche linee di ricerca sono: uso delle onde d'urto ad alta energia nel differenziamento di cellule staminali mesenchimali, targeted therapy e terapia sonodinamica con onde d'urto ad alta energia nelle neoplasie endocrine (Prof. Roberto Frairia); neoplasie ipofisarie, tiroidee e surrenaliche (attività di ricerca anche clinica), tumori neuroendocrini (Prof. Emanuela Arvat); carrier degli steroidi e loro recettori nelle neoplasie ormono-dipendenti (Prof. Roberto Frairia e Prof. Emanuela Arvat).

Prodotti della ricerca

Selezione di pubblicazioni:

Gallo M, Michelon F, Castiglione A, Felicetti F, Viansone AA, Nervo A, Zichi C, Ciccone G, Piovesan A, Arvat E. (2015) Sorafenib treatment of radioiodine-refractory advanced thyroid cancer in daily clinical practice: a cohort study from a single center. Endocrine 49(3) 726-34 [DOI  PMID]

Catalano MG, Marano F, Rinella L, de Girolamo L, Bosco O, Fortunati N, Berta L, Frairia R. (2014) Extracorporeal shockwaves (ESWs) enhance the osteogenic medium-induced differentiation of adipose-derived stem cells into osteoblast-like cells. Journal of tissue engineering and regenerative medicine [DOI  PMID]

Brignardello E, Palestini N, Felicetti F, Castiglione A, Piovesan A, Gallo M, Freddi M, Ricardi U, Gasparri G, Ciccone G, Arvat E, Boccuzzi G. (2014) Early surgery and survival of patients with anaplastic thyroid carcinoma: analysis of a case series referred to a single institution between 1999 and 2012. Thyroid : official journal of the American Thyroid Association 24(11) 1600-6 [DOI  PMID]

Pugliese M, Fortunati N, Germano A, Asioli S, Marano F, Palestini N, Frairia R, Boccuzzi G, Catalano MG. (2013) Histone deacetylase inhibition affects sodium iodide symporter expression and induces 131I cytotoxicity in anaplastic thyroid cancer cells. Thyroid : official journal of the American Thyroid Association 23(7) 838-46 [DOI  PMID]

Catalano MG, Fortunati N, Pugliese M, Marano F, Ortoleva L, Poli R, Asioli S, Bandino A, Palestini N, Grange C, Bussolati B, Boccuzzi G. (2012) Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. The Journal of clinical endocrinology and metabolism 97(7) E1150-9 [DOI  PMID]

Catalano MG, Pugliese M, Gargantini E, Grange C, Bussolati B, Asioli S, Bosco O, Poli R, Compagnone A, Bandino A, Mainini F, Fortunati N, Boccuzzi G. (2012) Cytotoxic activity of the histone deacetylase inhibitor panobinostat (LBH589) in anaplastic thyroid cancer in vitro and in vivo. International journal of cancer 130(3) 694-704 [DOI  PMID]

Fortunati N, Catalano MG, Marano F, Mugoni V, Pugliese M, Bosco O, Mainini F, Boccuzzi G. (2010) The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS). Breast cancer research and treatment 124(3) 667-75 [DOI  PMID]

Costantino L, Catalano MG, Frairia R, Carmazzi CM, Barbero M, Coluccia C, Donadio M, Genta F, Drogo M, Boccuzzi G, Fortunati N. (2009) Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure. Breast cancer research and treatment 114(3) 449-56 [DOI  PMID]

Catalano MG, Costantino L, Fortunati N, Bosco O, Pugliese M, Boccuzzi G, Berta L, Frairia R. (2007) High energy shock waves activate 5'-aminolevulinic Acid and increase permeability to Paclitaxel: antitumor effects of a new combined treatment on anaplastic thyroid cancer cells. Thyroid : official journal of the American Thyroid Association 17(2) 91-9 [DOI  PMID]

Giordano R, Bo M, Pellegrino M, Vezzari M, Baldi M, Picu A, Balbo M, Bonelli L, Migliaretti G, Ghigo E, Arvat E. (2005) Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade. The Journal of clinical endocrinology and metabolism 90(10) 5656-62 [DOI  PMID]