• Maria Felice Brizzi - Professoressa Associata responsabile del laboratorio
• Stefania Bruno - Professoressa Associata
• Dr.ssa Cristina Grange, Tecnico della Ricerca
• Dr. Alessandro Dottorando Sarcinella, Dottorando
• Dr. Gabriele Saccu, Dottorando
• Dr.ssa Giulia Chiabotto, Assegnista di Ricerca
• Dr.ssa Elena Ceccotti, Dottoranda
• Marta Tapparo, Borsista di ricerca
• Dr.ssa Saveria Femminò, Assegnista di Ricerca

• Laboratorio n. 7 (T151): Laboratorio di Biologia Molecolare
• Laboratorio n. 13 (T143): Laboratorio per lo studio funzionale delle vescicole extracellulari da cellule tumorali
• Laboratorio n. 14 (T148): Laboratorio di Proteomica delle malattie cardiovascolari
• Laboratorio n. 9: Laboratorio di Ricerca Traslazionale: isolamento e caratterizzazione funzionale di vescicole extracellulari per la rigenerazione tissutale 

Ospedale Molinette, piano terra, Corso Dogliotti 14, Torino

• mariafelice.brizzi@unito.it, 011/6336703
• stefania.bruno@unito.it, 011/6335539

• Prof.ssa Maria Felice Brizzi
• Dott. Stefania Bruno

1. Isolamento e caratterizzazione fenotipica, molecolare e funzionale di vescicole extracellulari da diverse fonti. 
2. Valutazione dell’attività pro-rigenerativa di vescicole extracellulari derivate da cellule staminali adulte umane in modelli di malattia renale acuta e cronica.
3. Studio dell’attività anti-fibrotica e anti-infiammatoria di vescicole extracellulari derivate da cellule staminali umane adulte in modelli in vivo ed in vitro di fibrosi epatica.
4. Analisi di bersagli terapeutici in tumori di diversa origine 
5. Nuovi approcci terapeutici utilizzando vescicole extracellulari ottenute dal siero di pazienti con malattie vascolari
6. Studio dei meccanismi responsabili della immunosoppressione tumorale mediata dalle vescicole extracellulari

• Pubblicazioni - ultimi 3 anni

• Chiabotto G, Ceccotti E, Tapparo M, Camussi G, Bruno S. Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype. Front Cell Dev Biol. 2021, 9:777462. 
• Bruno S, Chiabotto G, Cedrino M, Ceccotti E, Pasquino C, De Rosa S, Grange C, Tritta S, Camussi G. Extracellular Vesicles Derived from Human Liver Stem Cells Attenuate Chronic Kidney Disease Development in an In Vivo Experimental Model of Renal Ischemia and Reperfusion Injury. Int J Mol Sci. 2022;23(3):1485. 
• Gibello L, D'Antico S, Salafia M, Senetta R, Pomatto MAC, Orlando G, Sarcinella A, Lopatina T, Quaglino P, Lorenzi M, Verzini F, Camussi G, Brizzi MF. First pilot case-control interventional study using autologous extracellular vesicles to treat chronic venous ulcers unresponsive to conventional treatments. Pharmacol Res. 2023 Mar 5;190:106718. doi: 10.1016/j.phrs.2023.106718.
• Koni M, Castellano I, Venturelli E, Sarcinella A, Lopatina T, Grange C, Cedrino M, Femminò S, Cossu-Rocca P, Orrù S, D'Ascenzo F, Cotellessa I, Tampieri C, Debernardi C, Cugliari G, Matullo G, Camussi G, De Miglio MR, Brizzi MF. Interleukin-3-Receptor-α in Triple-Negative Breast Cancer (TNBC): An Additional Novel Biomarker of TNBC Aggressiveness and a Therapeutic Target. Cancers (Basel). 2022 Aug 13;14(16):3918. doi: 10.3390/cancers14163918.
• Lopatina T, Koni M, Grange C, Cedrino M, Femminò S, Lombardo G, Favaro E, Brizzi MF. IL-3 signalling in the tumour microenvironment shapes the immune response via tumour endothelial cell-derived extracellular vesicles. Pharmacol Res. 2022 May;179:106206. doi: 10.1016/j.phrs.2022.106206.

• PNRR: Drugs based on RNA technology. SPOKE: Cellular-derived vesicles as delivery system for RNA-based drugs.

• US11464799B2 (MF Brizzi, G. Camussi, A Ranghino). COMPOSITION OF EXTRACELLULAR VEPNRR: Drugs based on RNA technology. SPOKE: Cellular-derived vesicles as delivery system for RNA-based drugs.SICLES (EVS) AND MEDICAL USES THEREOF(Publication Date: 2022-10-11)

• US11110130B2 (MF Brizzi, G. Camussi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA (Publication Date: 2021-09-07)

• EA037967B1 (G. Camussi MF Brizzi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA (Publication Date: 2021-06-16)

• EP3010529B1 (MF Brizzi, E. Ghigo). USE OF UNACYLATED GHRELIN, FRAGMENTS AND ANALOGS THEREOF AS ANTIOXIDANT (Publication Date: 2020-05-06)

• EP3452100B1 (MF Brizzi, G. Camussi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA (Publication Date: 2020-12-16)

• US10716813B2 (MF Brizzi, G. Camussi). PHARMACEUTICAL CARRIERS CONTAINING MIRNAS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES CAUSED BY HYPERGLYCEMIA Publication Date: 2020-07-21

• CA2723270C (G. Muccioli, E. Ghigo, MF Brizzi) UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE (Publication Date: 2018-03-13)

• AU2009256558B2 (E. Ghigo, G. Muccioli, MF Brizzi). UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE (Publication Date: 2014-03-06)

• EP2310041B1 (MF Brizzi, G. Muccioli, E. Ghigo). UNACYLATED GHRELIN AND ANALOGS AS THERAPEUTIC AGENTS FOR VASCULAR REMODELING IN DIABETIC PATIENTS AND TREATMENT OF CARDIOVASCULAR DISEASE  (Publication date 2013-02-13)

• DK3452100T3 (G. Camussi, MF Brizzi). FARMACEUTISKE BÆRERE INDEHOLDENDE miRNAer TIL ANVENDELSE I BEHANDLINGEN AF FIBROTISKE SYGDOMME FORÅRSAGET AF HYPERGLYKÆMIA (Publication Date: 2021-03-08)

• ES2861650T3. PORTADORES FARMACÉUTICOS QUE CONTIENEN MIARN PARA SU USO EN EL TRATAMIENTO DE ENFERMEDADES FIBRÓTICAS PROVOCADAS POR HIPERGLUCEMIA (Publication Date: 2021-10-06)

• International patent: Bruno Stefania, Herrera Maria B)etariz, Fonsato Valentina, Camussi Giovanni, Tetta Ciro. (2011). “Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease”. WO2011107437 (A1)

• International patent: Camussi Giovanni, Bruno Stefania, Bussolati Benedetta (2011). “Isolated multipotent mesenchymal stem cells from human adult glomeruli (HGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney”. US2011256111 (A1), EP2186883 (A1)

• Interviste con studenti della scuola secondaria di primo livello per il progetto “donne STEM”