Fatty liver: Inhibition of Progression
Aree / Gruppi di ricerca
Partecipanti al progetto
Descrizione del progetto
The project FLIP (Fatty Liver: Inhibition of Progression) will study the mechanisms of progression of liver disease in NAFLD and suggest preventive and therapeutic strategies.
The project is based on the largest European cohort of patients with histologically diagnosed NAFLD, assembled with clinical and epidemiological data, and with biobanks of DNA, frozen liver tissue and serum.
It will span all the steps of the disease for studying cellular mechanisms of progression and answering key issues dealing with the interplay of metabolic, inflammatory and fibrotic factors in the initiation and perpetuation of liver injury.
It will create :
a prospective European cohort of patients with standardised inclusion criteria and histologically proven NAFLD/NASH,
a prospective European observatory of hepatocellular carcinoma in NASH.
It will conduct to :
the validation of improved diagnostic & prognostic markers for NAFLD,
the validation of consensual histological classification of NAFLD/NASH,
the identification of novel epidemiological determinants for NAFLD in adolescence and adulthood .