Gruppo

• Biochimica Clinica Endocrino-Metabolica
• Fisiopatologia vascolare traslazionale, retinopatia diabetica e pedagogia clinica: Brizzi/Bruno Lab

Nome inventori
MF Brizzi, E. Ghigo

Titolo brevetto
Use of unacylated ghrelin, fragments and analogs thereof as antioxidant

Data primo deposito
6/5/2020

Numero deposito
EP3010529B1

Link
https://patents.google.com/patent/EP3010529B1/en

Abstract
According to one aspect, the present invention relates to a fragment of unacylated ghrelin and/or pharmaceutically acceptable salts thereof wherein the fragment consists of amino acid sequence SEQ ID NO: 6 and/or pharmaceutically acceptable salts thereof, for its use in protecting a subject against reperfusion injury; particularly when the subject suffers from ischemia, or suffers from a stroke, or for protecting a subject from reperfusion injury following organ transplantation or for preventing ischemia-reperfusion injury in the subject. Particularly, the UAG fragment for the use of the invention modulates cellular levels of superoxide-dismutase-2 (SOD-2). The modulation of cellular levels of SOD-2 includes increasing cellular levels or expression of SOD-2.

Gruppo

• Biochimica Clinica Endocrino-Metabolica
• Fisiopatologia vascolare traslazionale, retinopatia diabetica e pedagogia clinica: Brizzi/Bruno Lab

Nome inventori
G. Muccioli, E. Ghigo, MF Brizzi

Titolo brevetto
Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease

Data primo deposito
13/03/2018

Numero deposito
CA2723270C

Link
https://pubchem.ncbi.nlm.nih.gov/patent/EP-2310041-A2

Abstract
The present invention relates to a method for treating a cardiovascular disease, for increasing the number of circulating angiogenic cells (CAC) and/or improving the function of CAC and a method for improving vascular remodeling and/or neovascularisation. The method comprises administering to the subject a therapeutically effective amount of unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1; and to pharmaceutical compositions comprising unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1.

Gruppo

• Biochimica Clinica Endocrino-Metabolica
• Fisiopatologia vascolare traslazionale, retinopatia diabetica e pedagogia clinica: Brizzi/Bruno Lab

Nome inventori
E. Ghigo, G. Muccioli, MF Brizzi

Titolo brevetto
Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease

Data primo deposito
06/03/2014

Numero deposito
AU2009256558B2

Gruppo

• Biochimica Clinica Endocrino-Metabolica
• Fisiopatologia vascolare traslazionale, retinopatia diabetica e pedagogia clinica: Brizzi/Bruno Lab

Nome inventori
MF Brizzi, G. Muccioli, E. Ghigo

Titolo brevetto
Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease

Data primo deposito
13/02/2013

Numero deposito
EP2310041B1 

Link
https://patents.google.com/patent/EP2310041B1/de

Gruppo
Laboratorio di Endocrinologia Molecolare e Cellulare

Nome Inventori
Ezio Ghigo, Aart Jan Van Der Lely, Riccarda Granata

Titolo brevetto
Unacylated ghrelin as therapeutic agent in the treatment of metabolic disorders

Data primo deposito
2010

Numero deposito
AA61K3802FI USPC

Link
https://iris.unito.it/handle/2318/68703

Abstract
An isolated polypeptide comprising any amino acid fragment of unacylated ghrelin or any analog thereof, wherein the polypeptide has an activity selected from the group consisting of a) decreasing blood glucose levels; b) increasing insulin secretion an/or sensitivity; c) binding to insulin-secreting cells; and d) promoting survival of insulin-secreting cells. As well as the use of the polypeptide in the treatment of a disorder associated with impaired glucose metabolism.