Dipartimento di Scienze Mediche

Prodotti della ricerca

Prodotti della ricerca selezionati

Vranic S, Marchio C, Castellano I, Botta C, Scalzo MS, Bender RP, Payan-Gomez C, di Cantogno LV, Gugliotta P, Tondat F, di Celle PF, Mariani S, Gatalica Z, Sapino A. (2015) Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast. Human pathology 46(9) 1350-9 [DOI  PMID]

Mariani S, Di Bello C, Bonello L, Tondat F, Pacchioni D, Molinaro L, Barreca A, Macri L, Chiusa L, di Celle PF, Cassoni P, Sapino A. (2015) Flexible lab-tailored cut-offs for suitability of formalin-fixed tumor samples for diagnostic mutational analyses. PloS one 10(4) e0121815 [DOI  PMID]

M Foglietta, B Castella, S Mariani, M Coscia, L Godio, R Ferracini, M Ruggeri, V Muccio, P Omede', , A Palumbo, M Boccadoro, M Massaia (2014)
The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespective of the disease status.
https://iris.unito.it/handle/2318/149006

Monica Boita, Giuseppe Guida, Paola Circosta, Angela Rita Elia, Stefania Stella, Enrico Heffler, Iuliana Badiu, Davide Martorana, Sara Mariani, Giovanni Rolla, Alessandro Cignetti (2014)
The molecular and functional characterization of clonally expanded CD8 + TCR BV T cells in eosinophilic granulomatosis with polyangiitis (EGPA).
https://iris.unito.it/handle/2318/143618

Asioli S, Maletta F, Pagni F, Pacchioni D, Vanzati A, Mariani S, Palestini N, Lloyd RV, Sapino A (2013)
Cytomorphologic and molecular features of hobnail variant of papillary thyroid carcinoma: Case series and literature review.
https://iris.unito.it/handle/2318/140962

Mariani S, Hwang SY, Foglietta M, Bonello L, Vitale C, Coscia M, Fiore F, Bruno B, Massaia M (2009)
Comprehensive assessment of the TCRBV repertoire in small T-cell samples by means of an improved and convenient multiplex PCR method.
https://iris.unito.it/handle/2318/67418

D', Armento G, Daniele L, Mariani S, Ottaviani D, Mussa A, Cassoni P, Sapino A, Bussolati G (2009)
Added value of combined gene and protein expression of CK20 and CEA in non-macroscopically involved lymph nodes of colorectal cancer.
https://iris.unito.it/handle/2318/63290

Daniele L, Annaratone L, Allia E, Mariani S, Armando E, Bosco M, Macrì L, Cassoni P, D', Armento G, Bussolati G, Cserni G, Sapino A (2009)
Technical limits of comparison of step-sectioning, immunohistochemistry and RT-PCR on breast cancer sentinel nodes: a study on methacarn fixed tissue.
https://iris.unito.it/handle/2318/56512

Giuseppe Guida, Antonella Vallario, Stefania Stella, Monica Boita, Paola Circosta, Sara Mariani, Giuseppina Prato, Enrico Heffler, Roberta Bergia, Antonino Sottile, Giovanni Rolla, Alessandro Cignetti (2008)
Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome.
https://iris.unito.it/handle/2318/57813

FIORE F, CASTELLA B, NUSCHAK B, BERTIERI R, MARIANI S, BRUNO B, PANTALEONI F, FOGLIETTA M, BOCCADORO M, MASSAIA M (2007)
Enhanced ability of dendritic cells to stimulate innate and adaptive immunity upon short-term incubation with zoledronic acid.
https://iris.unito.it/handle/2318/35887

Myriam Foglietta, Sara Mariani, Barbara Castella, Marta Coscia, Laura Godio, Serena Zappia, Mario Boccadoro, Massimo Massaia (2006)
Regulatory T Cells (Tregs) Are Highly Preserved in Multiple Myeloma Patients and Can Dominate Effector Functions.
https://iris.unito.it/handle/2318/67962

Foglietta M, Mariani S, Castella B, Coscia M, Boccadoro M, , , Massaia M (2006)
Frequency and function of regulatory T cells (Tregs) are highly preserved in multiple myeloma.
https://iris.unito.it/handle/2318/68216

Francesca Fiore, Barbara Castella, Barbara Nuschak, Raffaello Bertieri, Sara Mariani, Serena Zappia, Marta Coscia, Mario Boccadoro, Massimo Massaia (2006)
Dendritic Cells Can Be Primed to Concurrently Activate Both Unconventional Gamma/delta and Conventional alpha/beta T Cells.
https://iris.unito.it/handle/2318/68218

Ladetto M, Vallet S, Trojan A, Dell', aquila M, Monitillo L, Rosato R, Santo L, Drandi D, Bertola A, Falco P, Cavallo F, Ricca I, De Marco F, Mantoan B, Bode-Lesniewska B, Pagliano G, Francese R, Rocci A, Astolfi M, Compagno M, Mariani S, Godio L, Marino L, Ruggeri M, Omede P, Palumbo A, Boccadoro M (2005)
Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome.
https://iris.unito.it/handle/2318/41503

Mariani S, Muraro M, Pantaleoni F, Fiore F, Nuschak B, Peola S, Foglietta M, Palumbo A, Coscia M, Castella B, Bruno B, Bertieri R, Boano L, Boccadoro M, Massaia M (2005)
Effector gammadelta T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma.
https://iris.unito.it/handle/2318/41373

F FIORE, B NUSCHAK, S PEOLA, S MARIANI, M MURARO, M FOGLIETTA, M COSCIA, B BRUNO, M BOCCADORO, M MASSAIA (2005)
Exposure to myeloma cell lysates affects the immune competence of dendritic cells and favors the induction of Tr1-like regulatory T cells.
https://iris.unito.it/handle/2318/40461

COSCIA M, MARIANI S, BATTAGLIO S, DI BELLO C, FIORE F, FOGLIETTA M, PILERI A, BOCCADORO M, MASSAIA M (2004)
Long-term follow-up of idiotype vaccination in human myeloma as a maintenance therapy after high-dose chemotherapy.
https://iris.unito.it/handle/2318/40932

Fiore F, Nushack B, Peola S, Coscia M, Foglietta M, Canavese M, Mariani S, Muraro M, Bruno B, Boccadoro M, Massimo M (2004)
MYELOMA CELLS DRIVE THE MATURATION OF DENDRITIC CELLS VERSUS A TH2-PROMOTING PHENOTYPE WHICH IMPAIRS T-CELL ACTIVATION.
https://iris.unito.it/handle/2318/116986

Pantaleoni F, Mariani S, Muraro M, Peola S, Nuschak B, Foglietta M, Castella B, Fiore F, Coscia M, Boccadoro M, Massaia M (2004)
ROLE OF THE MEVALONATE PATHWAY IN THE IMMUNOMODULATORY ACTIVITY OF ZOLEDRONIC ACID.
https://iris.unito.it/handle/2318/127002

Fiore F, Nushack B, Peola S, Coscia M, Folgietta M, Canavese M, Mariani S, Muraro M, Bruno B, Boccadoro M, Massaia M (2003)
Myeloma cells drive the maturation of dendritic cells versus a Th2-promoting phenotype which impairs T-cell activation.
https://iris.unito.it/handle/2318/125324

MARIANI S, COSCIA M, EVEN J, PEOLA S, FOGLIETTA M, M BOCCADORO, SBAIZ L, RESTAGNO G, PILERI A, MASSAIA M (2001)
Severe and long-lasting disruption of T-cell receptor diversity in human myeloma after high-dose chemotherapy and autologous peripheral blood progenitor cell infusion.
https://iris.unito.it/handle/2318/43453

BESOSTRI B, BEGGIATO E, BIANCHI A, MARIANI S, COSCIA M, PEOLA S, FOGLIETTA M, BOCCADORO M, PILERI A, MORETTA L, MASSAIA M (2000)
Increased expression of non-functional killer inhibitory receptor CD94 in CD8+ cells of myeloma patients.
https://iris.unito.it/handle/2318/33857

MASSAIA M, BORRIONE P, BATTAGLIO S, MARIANI S, BEGGIATO E, NAPOLI P, VOENA C, BIANCHI A, COSCIA M, BESOSTRI B, PEOLA S, EVEN J, NOVERO D, M BOCCADORO, PILERI A (1999)
Idiotype vaccination in human myeloma: generation of tumor-specific immune responses after high-dose chemotherapy.
https://iris.unito.it/handle/2318/36404

BORRIONE P, PEOLA S, MARIANI M, BESOSTRI B, MALLONE R, MALAVASI F, PILERI A, M MASSAIA (1999)
CD38 stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the phosphatidylinositol 3-kinase pathway and inducing CD73 expression.
https://iris.unito.it/handle/2318/41820

A BIANCHI, S MARIANI, E BEGGIATO, P BORRIONE, S PEOLA, M BOCCADORO, A PILERI, M MASSAIA (1997)
Distribution of T-cell signalling molecules in human myeloma.
https://iris.unito.it/handle/2318/39228

Francia di Celle P, Mariani S, Riera L, Stacchini A, Reato G, Foa R (1996)
Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia cells by prolonging survival in an autocrine fashion.
https://iris.unito.it/handle/2318/101329

Temi di ricerca

Ambiti di ricerca affrontati: genetica ed istocompatibilità, ematologia ed immunoematologia anti-tumorale.

Attualmente si occupa di analisi mutazionali nei tumori solidi di pazienti possibili candidati a terapie target molecolari (adenocarcinomi del colon, del polmone e melanomi).

Principali competenze tecniche nei seguenti campi: biologia molecolare (DNA-RNA-proteine), biologia cellulare, citometria a flusso.

Buona conoscenza della lingua inglese, di programmi computerizzati e di particolari strumentazioni scientifiche (FACS, Sequenziatori automatici, Pyrosequenziatori, MALDI-Toff per sequenziamento acidi nucleici).

Gruppi di ricerca

• of anatomic and molecular Pathology